Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 628831
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Acc ID: CHEBI:16359
Term: cholic acid
Definition: A bile acid that is 5beta-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12.
Chemical ID: MESH:D019826
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Cholesterol, Dietary co-treated with Cholic Acid] results in increased activity of NR1H4 protein

PMID:14684380
affects bindingISORGD:7341036480464CTDCholic Acid binds to NR1H4 protein

PMID:19965603
increases activityISORGD:7341036480464CTDCholic Acid results in increased activity of NR1H4 protein

PMID:22561792
increases activityISORGD:7341046480464CTDCholic Acid results in increased activity of NR1H4 protein

PMID:15694933
increases expressionISORGD:7341036480464CTDCholic Acid results in increased expression of NR1H4 mRNA

PMID:25055961
increases phosphorylationISORGD:7341046480464CTDCholic Acid results in increased phosphorylation of NR1H4 protein

PMID:29968724
multiple interactionsISORGD:7341036480464CTD[[Cholic Acid results in increased activity of NR1H4 protein] which binds to FGF19 promoter] which results in increased expression of FGF19 mRNA, [Cholic Acid results in increased activity of NR1H4 protein] which binds to FGF19 promoter, Cholic Acid analog binds to and results in increased activity of NR1H4 protein, Cholic Acid binds to and results in increased activity of NR1H4 protein

PMID:13130122, PMID:22561792
multiple interactionsISORGD:7341046480464CTD[Cholic Acid binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA, [Cholic Acid binds to and results in increased activity of NR1H4 protein] which results in decreased expression of SLC10A1 mRNA, [Cholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of ABCB11 mRNA, [Cholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA, [Cholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of SCARB1 mRNA, [Cholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of SLC51B mRNA, [NR1H4 protein mutant form inhibits the reaction [Cholic Acid results in increased phosphorylation of NR1H4 protein]] which results in decreased expression of ABCA8 mRNA, [NR1H4 protein mutant form inhibits the reaction [Cholic Acid results in increased phosphorylation of NR1H4 protein]] which results in decreased expression of ABCA9 mRNA, [NR1H4 protein mutant form inhibits the reaction [Cholic Acid results in increased phosphorylation of NR1H4 protein]] which results in decreased expression of ABCB11 mRNA, [NR1H4 protein mutant form inhibits the reaction [Cholic Acid results in increased phosphorylation of NR1H4 protein]] which results in decreased expression of ABCG1 mRNA, [NR1H4 protein mutant form inhibits the reaction [Cholic Acid results in increased phosphorylation of NR1H4 protein]] which results in decreased expression of ABCG5 mRNA, [NR1H4 protein mutant form inhibits the reaction [Cholic Acid results in increased phosphorylation of NR1H4 protein]] which results in decreased expression of ABCG8 mRNA, [NR1H4 protein mutant form inhibits the reaction [Cholic Acid results in increased phosphorylation of NR1H4 protein]] which results in decreased expression of ATP8B1 mRNA, [NR1H4 protein mutant form inhibits the reaction [Cholic Acid results in increased phosphorylation of NR1H4 protein]] which results in decreased expression of SCARB1 mRNA, Cholic Acid binds to and results in increased activity of NR1H4 protein, Cholic Acid promotes the reaction [SRC protein binds to NR1H4 protein], Cholic Acid results in increased phosphorylation of and results in increased activity of NR1H4 protein, NR1H4 gene mutant form inhibits the reaction [Cholic Acid results in increased expression of SOD3 mRNA], NR1H4 protein mutant form inhibits the reaction [Cholic Acid results in increased phosphorylation of NR1H4 protein], NR1H4 protein promotes the reaction [Cholic Acid results in increased expression of LRP2 protein]

PMID:15375181, PMID:22540009, PMID:25496033, PMID:29968724, PMID:30996006
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.