GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69057
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:16359
Term: cholic acid
Definition: A bile acid that is 5beta-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12.
Chemical ID: MESH:D019826
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISOCRRD:691056480464CTDCholic Acid metabolite results in increased activity of NR1I2 protein

Cholic Acid results in increased activity of NR1I2 protein

PMID:27871908
increases expressionISOCRRD:691066480464CTDCholic Acid results in increased expression of NR1I2 mRNA

PMID:25582706
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.