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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2443
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cth
Name: cystathionine gamma-lyase
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDLipopolysaccharides results in decreased expression of CTH protein

PMID:21308383
increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of CTH mRNA

PMID:16491094
multiple interactionsEXP 6480464CTD[Lipopolysaccharides results in decreased expression of CTH protein] which results in decreased chemical synthesis of Hydrogen Sulfide, Cysteine analog promotes the reaction [[Lipopolysaccharides results in decreased expression of CTH protein] which results in decreased chemical synthesis of Hydrogen Sulfide], nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of CTH mRNA]

PMID:16491094, PMID:21308383
decreases expressionISORGD:7320846480464CTDLipopolysaccharides results in decreased expression of CTH mRNA, Lipopolysaccharides results in decreased expression of CTH protein

PMID:29128401
increases response to substanceISORGD:7320856480464CTDCTH protein mutant form results in increased susceptibility to Lipopolysaccharides

PMID:29128401
multiple interactionsISORGD:7320846480464CTDTLR4 mRNA promotes the reaction [Lipopolysaccharides results in decreased expression of CTH protein]

PMID:29128401
multiple interactionsISORGD:7320856480464CTD[CTH protein mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL4 mRNA, [CTH protein mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL4 protein, [CTH protein mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL6 protein, CTH protein mutant form promotes the reaction [Lipopolysaccharides results in increased expression of IL2 mRNA], CTH protein mutant form promotes the reaction [Lipopolysaccharides results in increased expression of IL2 protein], CTH protein mutant form promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA], CTH protein mutant form promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA], CTH protein mutant form promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein], Lipopolysaccharides promotes the reaction [CTH protein mutant form results in increased expression of IL2 mRNA], Lipopolysaccharides promotes the reaction [CTH protein mutant form results in increased expression of IL2 protein], Lipopolysaccharides promotes the reaction [CTH protein mutant form results in increased expression of IL4 mRNA], Lipopolysaccharides promotes the reaction [CTH protein mutant form results in increased expression of IL4 protein], Lipopolysaccharides promotes the reaction [CTH protein mutant form results in increased expression of IL6 mRNA]

PMID:29128401
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.