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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3153
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ncl
Name: nucleolin
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDLipopolysaccharides binds to NCL protein

PMID:21309751
increases uptakeEXP 6480464CTDNCL protein results in increased uptake of Lipopolysaccharides

PMID:21309751
multiple interactionsEXP 6480464CTD[NCL protein results in increased uptake of Lipopolysaccharides] which results in increased expression of IL6 protein, [NCL protein results in increased uptake of Lipopolysaccharides] which results in increased expression of TNF protein

PMID:21309751
multiple interactionsISORGD:15530776480464CTDNCL protein inhibits the reaction [Lipopolysaccharides results in increased activity of STAT1 protein], NCL protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA], NCL protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein], NCL protein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA], NCL protein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein], NCL protein inhibits the reaction [Lipopolysaccharides results in increased localization of and results in increased activity of NFKB1 protein]

PMID:21309717
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.