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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3952
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Vcam1
Name: vascular cell adhesion molecule 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of VCAM1 mRNA

PMID:22903158
increases expressionISOCRRD:114816480464CTDLipopolysaccharides results in increased expression of VCAM1 mRNA

Lipopolysaccharides results in increased expression of VCAM1 protein

PMID:12892526, PMID:21300114, PMID:22185406, PMID:23170834, PMID:27183587
increases expressionISOCRRD:7309886480464CTDLipopolysaccharides results in increased expression of VCAM1 mRNA

Lipopolysaccharides results in increased expression of VCAM1 protein

PMID:12615669, PMID:15358673, PMID:16317058, PMID:19426978, PMID:21371465, PMID:22007554, PMID:27183587, PMID:29128401
multiple interactionsISOCRRD:114816480464CTD[Lipopolysaccharides co-treated with Dietary Fats] results in increased expression of VCAM1 mRNA

[Lipopolysaccharides co-treated with Dietary Fats] results in increased expression of VCAM1 protein

[Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of VCAM1 mRNA

CAP18 lipopolysaccharide-binding protein inhibits the reaction [[Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of VCAM1 mRNA]

caryophyllene inhibits the reaction [[Lipopolysaccharides co-treated with Dietary Fats] results in increased expression of VCAM1 mRNA]

caryophyllene inhibits the reaction [[Lipopolysaccharides co-treated with Dietary Fats] results in increased expression of VCAM1 protein]

Cycloheximide inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]

Dactinomycin inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]

Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]

Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]

IFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]

pirinixic acid inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]

Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]

tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]

PMID:12892526, PMID:21300114, PMID:21731756, PMID:22185406, PMID:23170834, PMID:28624443
multiple interactionsISOCRRD:7309886480464CTD22-hydroxycholesterol promotes the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]

24,25-epoxycholesterol promotes the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]

3,4-dihydroxyphenylethanol inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]

3,4-dihydroxyphenylethanol inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]

Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]

bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]]

DDX58 protein affects the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]

DDX58 protein affects the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]

DDX58 protein affects the reaction [TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]]

Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]

Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]

GW 3965 inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]

Hydrocortisone inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]

hydroxysafflor yellow A inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]

MAVS protein affects the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]

Medroxyprogesterone Acetate inhibits the reaction [Hydrocortisone inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]]

Medroxyprogesterone Acetate inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]

Mifepristone inhibits the reaction [Medroxyprogesterone Acetate inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]]

Mifepristone inhibits the reaction [Progesterone inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]]

oleuropein inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]

oleuropein inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]

Org 31710 inhibits the reaction [Progesterone inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]]

Progesterone inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]

Quercetin promotes the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]

Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]

Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]

sodium bisulfide inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]

TLR4 protein affects the reaction [DDX58 protein affects the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]]

TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]

TO-901317 inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]

PMID:12615669, PMID:15358673, PMID:16317058, PMID:19426978, PMID:21371465, PMID:22007554, PMID:27183587, PMID:29128401, PMID:9846848
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.