GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620048
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Sphk1
Name: sphingosine kinase 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of SPHK1 mRNA

Lipopolysaccharides results in increased expression of SPHK1 protein

PMID:16415329, PMID:25557508
multiple interactionsEXP 6480464CTDApigenin inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein]

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SPHK1 mRNA]

PMID:16415329, PMID:25557508
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.