CRRD ID: 620048
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Sphk1
Name: sphingosine kinase 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of SPHK1 mRNA

Lipopolysaccharides results in increased expression of SPHK1 protein

PMID:16415329, PMID:25557508
multiple interactionsEXP 6480464CTDApigenin inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein]

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SPHK1 mRNA]

PMID:16415329, PMID:25557508
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.