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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61312
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:164200
Term: triclosan
Definition: An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes.
Chemical ID: MESH:D014260
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7339066480464CTDTriclosan results in decreased expression of TIMP2 mRNA

PMID:26604029
multiple interactionsISORGD:7339066480464CTD[Progesterone co-treated with Triclosan] results in decreased expression of TIMP2 mRNA

PMID:26604029
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.