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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2835
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Hsd11b2
Name: hydroxysteroid 11-beta dehydrogenase 2
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in increased expression of HSD11B2 mRNA

PMID:26496021
decreases expressionISORGD:7374686480464CTDEstradiol results in decreased expression of HSD11B2 protein

PMID:17515840
increases expressionISORGD:7374686480464CTDEstradiol results in increased expression of HSD11B2 mRNA

PMID:23019147
multiple interactionsISORGD:107356480464CTD[bisphenol A results in increased susceptibility to Estradiol] which results in decreased expression of HSD11B2 mRNA

PMID:27312807
multiple interactionsISORGD:7374686480464CTD[Estradiol binds to ESR2 protein] which results in increased expression of HSD11B2 mRNA, [Estradiol co-treated with Progesterone] results in increased expression of HSD11B2 mRNA, [Estradiol co-treated with TGFB1 protein] results in decreased expression of HSD11B2 mRNA

PMID:20404318, PMID:20660070, PMID:30165855
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.