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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61312
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7339066480464CTDEstradiol results in decreased expression of TIMP2 mRNA, Estradiol results in decreased expression of TIMP2 protein

PMID:19167446, PMID:19956873
multiple interactionsISORGD:7339066480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of TIMP2 mRNA], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of TIMP2 protein], fulvestrant inhibits the reaction [Estradiol results in decreased expression of TIMP2 mRNA], fulvestrant inhibits the reaction [Estradiol results in decreased expression of TIMP2 protein]

PMID:19956873
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.