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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 631434
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Bbc3
Name: Bcl-2 binding component 3
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISOCRRD:15524846480464CTDEstradiol results in decreased expression of BBC3 mRNA

PMID:22467019
decreases expressionISOCRRD:7353896480464CTDEstradiol results in decreased expression of BBC3 mRNA

PMID:25321415
increases expressionISOCRRD:7353896480464CTDEstradiol results in increased expression of BBC3 mRNA

PMID:23373633
multiple interactionsISOCRRD:7353896480464CTDEstradiol inhibits the reaction [Benzo(a)pyrene results in increased expression of BBC3 protein]

Estradiol inhibits the reaction [dibenzo(a,l)pyrene affects the expression of BBC3 protein]

Okadaic Acid inhibits the reaction [Estradiol inhibits the reaction [Benzo(a)pyrene results in increased expression of BBC3 protein]]

PMID:24954032
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.