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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 70924
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Pdzk1
Name: PDZ domain containing 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:7328236480464CTDEstradiol affects the expression of PDZK1 mRNA

PMID:14699072
increases expressionISORGD:7328236480464CTDEstradiol results in increased expression of PDZK1 mRNA

PMID:14605097, PMID:15159206, PMID:15757668, PMID:16393665, PMID:19167446, PMID:19619570, PMID:21185374, PMID:21795739, PMID:26865669, PMID:26921789, PMID:28711546
multiple interactionsISORGD:7328236480464CTD[Estradiol binds to ESR2 protein] which results in increased expression of PDZK1 mRNA, [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PDZK1 mRNA, [Estradiol co-treated with TGFB1 protein] results in increased expression of PDZK1 mRNA, Fulvestrant inhibits the reaction [Estradiol results in increased expression of PDZK1 mRNA], Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of PDZK1 mRNA], Tamoxifen inhibits the reaction [Estradiol results in increased expression of PDZK1 mRNA]

PMID:14605097, PMID:19619570, PMID:20404318, PMID:21185374, PMID:30165855
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.