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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 731380
Species: Homo sapiens
CRRD Object: Gene
Symbol: AIFM1
Name: apoptosis inducing factor mitochondria associated 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDEstradiol affects the expression of AIFM1 mRNA

PMID:21826169
decreases expressionEXP 6480464CTDEstradiol results in decreased expression of AIFM1 mRNA

PMID:23373633
multiple interactionsEXP 6480464CTDESR1 protein affects the reaction [Estradiol inhibits the reaction [Hydrogen Peroxide affects the localization of AIFM1 protein]], Estradiol inhibits the reaction [Hydrogen Peroxide affects the localization of AIFM1 protein], Estradiol promotes the reaction [N-(oxo-5, 6-dihydrophenanthridin-2-yl)-N, N-dimethylacetamide hydrochloride inhibits the reaction [Hydrogen Peroxide affects the localization of AIFM1 protein]], N-(oxo-5, 6-dihydrophenanthridin-2-yl)-N, N-dimethylacetamide hydrochloride promotes the reaction [Estradiol inhibits the reaction [Hydrogen Peroxide affects the localization of AIFM1 protein]]

PMID:25280774
multiple interactionsISORGD:7313816480464CTDEstradiol affects the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of AIFM1 mRNA]

PMID:24412242
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.