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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 736279
Species: Homo sapiens
CRRD Object: Gene
Symbol: SYTL5
Name: synaptotagmin like 5
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDEstradiol results in increased expression of SYTL5 mRNA

PMID:19167446, PMID:21185374, PMID:24758408
multiple interactionsEXP 6480464CTD[Estradiol binds to ESR2 protein] which results in increased expression of SYTL5 mRNA, [Estradiol co-treated with Progesterone] results in decreased expression of SYTL5 mRNA, EGF protein promotes the reaction [Estradiol results in increased expression of SYTL5 mRNA]

PMID:20404318, PMID:20660070, PMID:24758408
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.