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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 737414
Species: Mus musculus
CRRD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7374136480464CTDEstradiol results in decreased expression of CDH1 mRNA, Estradiol results in decreased expression of CDH1 protein

PMID:20106945, PMID:25690688, PMID:26407941, PMID:27539251, PMID:28844962
multiple interactionsISORGD:7374136480464CTD3, 3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of CDH1 protein], fulvestrant inhibits the reaction [Estradiol results in decreased expression of CDH1 protein], Genistein inhibits the reaction [Estradiol results in decreased expression of CDH1 protein], plerixafor octahydrochloride inhibits the reaction [Estradiol results in decreased expression of CDH1 protein]

PMID:25690688, PMID:26407941, PMID:27539251, PMID:28844962
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.