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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 733705
Species: Homo sapiens
CRRD Object: Gene
Symbol: CTNNB1
Name: catenin beta 1
Acc ID: CHEBI:16598
Term: DDE
Definition: A chlorophenylethylene that is ethylene substituted by two 4-chlorophenyl groups at position 1 and two chlorine atoms at position 2.
Chemical ID: MESH:D003633
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects activityEXP 6480464CTDDichlorodiphenyl Dichloroethylene affects the activity of CTNNB1 protein

PMID:25386960
increases activityEXP 6480464CTDDichlorodiphenyl Dichloroethylene results in increased activity of CTNNB1 protein

PMID:27589886
multiple interactionsEXP 6480464CTDCTNNB1 affects the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of CCND1 protein], CTNNB1 affects the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of MYC protein]

PMID:25386960
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.