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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620800
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Bnip3
Name: BCL2 interacting protein 3
Acc ID: CHEBI:16602
Term: trichloroethene
Definition: A member of the class of chloroethenes that is ethene substituted by chloro groups at positions 1, 1 and 2.
Chemical ID: MESH:D014241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of BNIP3 mRNA

PMID:17905399
increases expressionISORGD:7338146480464CTDTrichloroethylene results in increased expression of BNIP3 mRNA

PMID:15363585, PMID:28973375
multiple interactionsISORGD:7338146480464CTDPPARA protein inhibits the reaction [Trichloroethylene results in increased expression of BNIP3 protein]

PMID:15363585
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.