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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730927
Species: Homo sapiens
CRRD Object: Gene
Symbol: IL5
Name: interleukin 5
Acc ID: CHEBI:16602
Term: trichloroethene
Definition: A member of the class of chloroethenes that is ethene substituted by chloro groups at positions 1, 1 and 2.
Chemical ID: MESH:D014241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:107996480464CTDTrichloroethylene results in decreased expression of IL5 protein

PMID:16806339
increases methylationISORGD:29006480464CTDTrichloroethylene results in increased methylation of IL5 gene

PMID:27618143
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.