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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 68945
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp4a1
Name: cytochrome P450, family 4, subfamily a, polypeptide 1
Acc ID: CHEBI:16814
Term: dehydroepiandrosterone sulfate
Definition: A steroid sulfate that is the 3-sulfooxy derivative of dehydroepiandrosterone.
Chemical ID: MESH:D019314
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDDehydroepiandrosterone Sulfate results in increased expression of CYP4A1 mRNA, Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 protein

PMID:25786523, PMID:8700121
multiple interactionsEXP 6480464CTD[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP4A1 protein

PMID:25786523
increases expressionISORGD:16233166480464CTDDehydroepiandrosterone Sulfate results in increased expression of CYP4A1 mRNA

PMID:8700121
multiple interactionsISORGD:16233166480464CTDPPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 mRNA]

PMID:8700121
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.