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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620029
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr4a1
Name: nuclear receptor subfamily 4, group A, member 1
Acc ID: CHEBI:16856
Term: glutathione
Definition: A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine.
Chemical ID: MESH:D005978
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7327516480464CTDGlutathione inhibits the reaction [NR4A1 protein affects the cleavage of ATF4 protein], Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of CASP7 protein], Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of CASP8 protein], Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of PARP protein], Glutathione inhibits the reaction [NR4A1 protein affects the expression of DDIT3 protein], Glutathione inhibits the reaction [NR4A1 protein affects the expression of SESN2 protein], Glutathione inhibits the reaction [NR4A1 protein affects the expression of XBP1 protein alternative form], Glutathione inhibits the reaction [NR4A1 protein affects the phosphorylation of EIF2AK3 protein]

PMID:24515801, PMID:26035713
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.