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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730881
Species: Homo sapiens
CRRD Object: Gene
Symbol: HRAS
Name: HRas proto-oncogene, GTPase
Acc ID: CHEBI:16907
Term: 4-nitroquinoline N-oxide
Definition: A quinoline N-oxide carrying a nitro substituent at position 4.
Chemical ID: MESH:D015112
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of CCND1 mRNA, [4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA, nimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of CCND1 mRNA], nimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA]

PMID:20043093
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.