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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1323510
Species: Mus musculus
CRRD Object: Gene
Symbol: Akr1c21
Name: aldo-keto reductase family 1, member C21
Acc ID: CHEBI:16914
Term: salicylic acid
Definition: A monohydroxybenzoic acid that is benzoic acid with a hydroxy group at the ortho position. It is obtained from the bark of the white willow and wintergreen leaves.
Chemical ID: MESH:D020156
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:13539016480464CTDSalicylic Acid results in decreased activity of AKR1C2 protein

PMID:19010312
increases expressionISORGD:13539016480464CTDSalicylic Acid results in increased expression of AKR1C2 mRNA

PMID:20491607
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.