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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2894
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Il1rl1
Name: interleukin 1 receptor-like 1
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDProgesterone results in decreased expression of IL1RL1 mRNA

PMID:20726854
increases expressionISORGD:7361586480464CTDProgesterone results in increased expression of IL1RL1 mRNA

PMID:17404688, PMID:18692832
increases expressionISORGD:7361596480464CTDProgesterone results in increased expression of IL1RL1 mRNA

PMID:19000923
multiple interactionsISORGD:7361586480464CTD[Progesterone co-treated with Estradiol] results in increased expression of IL1RL1 mRNA

PMID:17404688, PMID:18692832
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.