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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3543
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Rbp1
Name: retinol binding protein 1
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:112216480464CTD[Estradiol co-treated with Progesterone] results in increased expression of RBP1 mRNA, [Progesterone co-treated with Estrogens] results in increased expression of RBP1 mRNA, [Progesterone results in increased activity of PGR protein] which results in increased expression of RBP1 mRNA, IGF1 protein inhibits the reaction [[Progesterone co-treated with Estrogens] results in increased expression of RBP1 mRNA]

PMID:15845616, PMID:18556351, PMID:18562952
multiple interactionsISORGD:7323916480464CTD[Estradiol co-treated with Progesterone] results in decreased expression of RBP1 mRNA

PMID:20660070
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.