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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61967
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Mcm6
Name: minichromosome maintenance complex component 6
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDProgesterone results in decreased expression of MCM6 mRNA

PMID:20726854
affects localizationISORGD:622606480464CTDProgesterone affects the localization of MCM6 protein

PMID:16966611
decreases expressionISORGD:622606480464CTDProgesterone results in decreased expression of MCM6 mRNA

PMID:16966611
multiple interactionsISORGD:622606480464CTDEstradiol inhibits the reaction [Progesterone affects the localization of MCM6 protein]

PMID:16966611
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.