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CRRD ID: 69224
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Gpx3
Name: glutathione peroxidase 3
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDProgesterone results in increased expression of GPX3 mRNA

affects expressionISORGD:7373826480464CTDProgesterone affects the expression of GPX3 mRNA

increases expressionISORGD:13438586480464CTDProgesterone results in increased expression of GPX3 mRNA

multiple interactionsISORGD:7373826480464CTD[Estradiol co-treated with Progesterone] results in increased expression of GPX3 mRNA

PMID:18556351, PMID:19693291
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.