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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620575
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Apaf1
Name: apoptotic peptidase activating factor 1
Acc ID: CHEBI:17154
Term: nicotinamide
Definition: A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
Chemical ID: MESH:D009536
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7332946480464CTD[Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene results in decreased expression of APAF1 mRNA], [Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene results in decreased expression of APAF1 protein], Niacinamide inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene results in decreased expression of APAF1 mRNA], Niacinamide inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene results in decreased expression of APAF1 protein]

PMID:25478867
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.