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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2661
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Gapdh
Name: glyceraldehyde-3-phosphate dehydrogenase
Acc ID: CHEBI:17234
Term: glucose
Definition: An aldohexose used as a source of energy and metabolic intermediate.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[chloroacetaldehyde results in decreased activity of GAPDH protein] which results in decreased chemical synthesis of Glucose, UCP1 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]

PMID:11050244, PMID:19733226
increases expressionISORGD:7358716480464CTDGlucose results in increased expression of GAPDH mRNA

PMID:7826318
multiple interactionsISORGD:7358716480464CTDSOD2 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]

PMID:11050244
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.