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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61312
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:17243
Term: mono(2-ethylhexyl) phthalate
Definition: The mono(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:C016599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDmono-(2-ethylhexyl)phthalate results in decreased expression of TIMP2 mRNA, mono-(2-ethylhexyl)phthalate results in decreased expression of TIMP2 protein

PMID:21832167
multiple interactionsEXP 6480464CTDColforsin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of TIMP2 protein]

PMID:21832167
decreases expressionISORGD:621786480464CTDmono-(2-ethylhexyl)phthalate results in decreased expression of TIMP2 mRNA, mono-(2-ethylhexyl)phthalate results in decreased expression of TIMP2 protein

PMID:21832167
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.