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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2456
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:17252
Term: 17alpha-hydroxyprogesterone
Definition: A 17alpha-hydroxy steroid that is the 17alpha-hydroxy derivative of progesterone.
Chemical ID: MESH:D019326
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp17a1affects abundanceISORGD:13505406480464CTDCYP17A1 protein affects the abundance of 17-alpha-Hydroxyprogesterone

PMID:21427057
Cyp17a1affects chemical synthesisISORGD:13505406480464CTDCYP17A1 protein affects the chemical synthesis of 17-alpha-Hydroxyprogesterone

PMID:16030167
Cyp17a1affects metabolic processingISORGD:13505406480464CTDCYP17A1 protein affects the metabolism of 17-alpha-Hydroxyprogesterone

PMID:16030167
Cyp17a1increases metabolic processingISORGD:13505406480464CTDCYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone

PMID:29100959
Cyp17a1multiple interactionsISORGD:13505406480464CTD[[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone, [CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone, [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione, Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone], Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione], Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone], TNF protein inhibits the reaction [CYP17A1 protein affects the metabolism of 17-alpha-Hydroxyprogesterone], Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone], Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione], Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone]

PMID:16030167, PMID:17194026, PMID:29100959
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.