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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 737414
Species: Mus musculus
CRRD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:692796480464CTDTestosterone results in decreased expression of CDH1 mRNA

PMID:27866977
multiple interactionsISORGD:692796480464CTD[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 mRNA, [Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 protein, Finasteride inhibits the reaction [Testosterone results in decreased expression of CDH1 mRNA], Qing Ye Dan inhibits the reaction [Testosterone results in decreased expression of CDH1 mRNA], Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 mRNA], Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 protein], swertiamarin inhibits the reaction [Testosterone results in decreased expression of CDH1 mRNA]

PMID:25164625, PMID:27866977
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.