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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621295
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Mvk
Name: mevalonate kinase
Acc ID: CHEBI:17447
Term: geraniol
Definition: A monoterpenoid consisting of two prenyl units linked head-to-tail and functionalised with a hydroxy group at its tail end.
Chemical ID: MESH:C007836
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7320316480464CTDgeraniol inhibits the reaction [[MVK gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL1B protein], geraniol inhibits the reaction [MVK gene mutant form results in increased susceptibility to Lipopolysaccharides]

PMID:20304105
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.