GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2466
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp2b1
Name: cytochrome P450, family 2, subfamily b, polypeptide 1
Acc ID: CHEBI:17578
Term: toluene
Definition: The simplest member of the class toluenes consisting of a benzene core which bears a single methyl substituent.
Chemical ID: MESH:D014050
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDToluene results in increased expression of CYP2B1 protein

PMID:8135039
increases oxidationEXP 6480464CTDCYP2B1 protein results in increased oxidation of Toluene

PMID:1994898
multiple interactionsEXP 6480464CTD[Phenobarbital results in increased expression of CYP2B1 protein] which results in increased metabolism of Toluene

Phenobarbital promotes the reaction [CYP2B1 protein results in increased oxidation of Toluene]

PMID:1994898, PMID:9010585
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.