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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1303274
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Dnmt3b
Name: DNA methyltransferase 3 beta
Acc ID: CHEBI:175901
Term: gemcitabine
Definition: A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.
Chemical ID: MESH:C056507
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISOCRRD:16060376480464CTD[gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of DNMT3B protein

PMID:25189999
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.