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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61312
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:17594
Term: hydroquinone
Definition: A benzenediol comprising benzene core carrying two hydroxy substituents para to each other.
Chemical ID: MESH:C031927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7339066480464CTD[MMP14 protein co-treated with TIMP2 protein] inhibits the reaction [hydroquinone results in decreased activity of MMP2 protein], [TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of COL1A1 protein], [TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of COL4A1 protein], [TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of LAMA4 protein], TIMP2 protein inhibits the reaction [hydroquinone results in decreased activity of MMP2 protein], TIMP2 protein inhibits the reaction [hydroquinone results in increased expression of COL1A1 protein], TIMP2 protein inhibits the reaction [hydroquinone results in increased expression of COL4A1 protein], TIMP2 protein inhibits the reaction [hydroquinone results in increased expression of LAMA4 protein]

PMID:18055817
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.