GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2456
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:17642
Term: pentachlorophenol
Definition: A chlorophenol that is phenol substituted by 5 chloro groups.
Chemical ID: MESH:D010416
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISOCRRD:13505406480464CTDPentachlorophenol results in decreased expression of CYP17A1 mRNA

PMID:21296122
increases expressionISOCRRD:7372226480464CTDPentachlorophenol results in increased expression of CYP17A1 mRNA

PMID:23892564
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.