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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2456
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDNicotine results in decreased expression of CYP17A1 mRNA

Nicotine results in decreased expression of CYP17A1 protein

PMID:27782041, PMID:28986172
decreases expressionISOCRRD:13505406480464CTDNicotine results in decreased expression of CYP17A1 mRNA

PMID:24709674
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.