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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61800
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Htr2a
Name: 5-hydroxytryptamine receptor 2A
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDNicotine results in increased expression of HTR2A protein

PMID:30247698
multiple interactionsEXP 6480464CTD[Nicotine co-treated with Benzo(a)pyrene] results in decreased expression of HTR2A protein, Nicotine results in increased activity of [HTR1B protein binds to HTR2A protein]

PMID:21316381, PMID:30247698
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.