Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 11250
Species: Mus musculus
CRRD Object: Gene
Symbol: Rxra
Name: retinoid X receptor alpha
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDCalcitriol affects the expression of RXRA protein

PMID:16368784
affects localizationEXP 6480464CTDCalcitriol affects the localization of RXRA protein

PMID:15647825
multiple interactionsEXP 6480464CTDCalcitriol promotes the reaction [RXRA protein binds to CYP24A1 promoter], Calcitriol promotes the reaction [RXRA protein binds to SPP1 promoter]

PMID:15647825
affects response to substanceISORGD:7369296480464CTDRXRA protein affects the susceptibility to Calcitriol

PMID:25279795
increases phosphorylationISORGD:7369296480464CTDCalcitriol results in increased phosphorylation of RXRA protein

PMID:20371703
multiple interactionsISORGD:7369296480464CTD[alitretinoin co-treated with Calcitriol] results in increased stability of [RXRA protein binds to VDR protein], [Calcitriol binds to VDR protein] promotes the reaction [VDR protein binds to RXRA protein], [Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] inhibits the reaction [PPARGC1A protein results in increased expression of CYP7A1 mRNA], [Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] which results in decreased expression of CYP7A1 mRNA, [Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA, Benzo(a)pyrene inhibits the reaction [Calcitriol promotes the reaction [RXRA protein binds to CYP24A1 promoter]], Calcitriol promotes the reaction [[VDR protein binds to RXRA protein] which binds to CYP24A1 promoter], Calcitriol promotes the reaction [[VDR protein binds to RXRA protein] which binds to SLC30A10 promoter], Calcitriol promotes the reaction [MAPK1 protein results in increased phosphorylation of RXRA protein], Calcitriol promotes the reaction [MAPK3 protein results in increased phosphorylation of RXRA protein], Calcitriol promotes the reaction [RXRA protein binds to and results in increased activity of VDR protein], Calcitriol promotes the reaction [RXRA protein binds to and results in increased activity of VDRA protein], Calcitriol promotes the reaction [RXRA protein binds to and results in increased activity of VDRALPHA protein], Calcitriol promotes the reaction [RXRA protein binds to and results in increased activity of VDRB protein], Calcitriol promotes the reaction [RXRA protein binds to CYP24A1 mRNA], Calcitriol promotes the reaction [RXRA protein binds to CYP24A1 promoter], Calcitriol promotes the reaction [RXRA protein binds to CYP7A1 mRNA], Calcitriol promotes the reaction [RXRA protein mutant form binds to VDRA protein], Calcitriol promotes the reaction [RXRA protein mutant form binds to VDRALPHA protein], Calcitriol promotes the reaction [RXRA protein mutant form binds to VDRB protein], Calcitriol promotes the reaction [salvin results in increased expression of RXRA protein], Calcitriol promotes the reaction [VDR protein binds to RXRA protein], Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein], NCOA1 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein binds to and results in increased activity of VDR protein]], NCOA1 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein binds to and results in increased activity of VDRA protein]], NCOA1 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein binds to and results in increased activity of VDRALPHA protein]], NCOA1 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein binds to and results in increased activity of VDRB protein]], NCOA1 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein mutant form binds to VDRA protein]], NCOA1 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein mutant form binds to VDRALPHA protein]], NCOA1 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein mutant form binds to VDRB protein]], NCOA2 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein results in increased activity of VDR protein]], NCOA2 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein results in increased activity of VDRA protein]], NCOA2 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein results in increased activity of VDRALPHA protein]], NCOA2 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein results in increased activity of VDRB protein]], NCOA3 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein results in increased activity of VDR protein]], NCOA3 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein results in increased activity of VDRA protein]], NCOA3 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein results in increased activity of VDRALPHA protein]], NCOA3 protein promotes the reaction [Calcitriol promotes the reaction [RXRA protein results in increased activity of VDRB protein]], NCOR1 protein inhibits the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA], NCOR1 protein promotes the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] inhibits the reaction [PPARGC1A protein results in increased expression of CYP7A1 mRNA]], NCOR2 protein inhibits the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA], NCOR2 protein promotes the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] inhibits the reaction [PPARGC1A protein results in increased expression of CYP7A1 mRNA]], PPARGC1A protein promotes the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA], RXRA protein inhibits the reaction [Calcitriol promotes the reaction [NCOA1 protein binds to VDRA protein]], RXRA protein inhibits the reaction [Calcitriol promotes the reaction [NCOA1 protein binds to VDRALPHA protein]], RXRA protein inhibits the reaction [Calcitriol promotes the reaction [NCOA2 protein binds to VDRA protein]], RXRA protein inhibits the reaction [Calcitriol promotes the reaction [NCOA2 protein binds to VDRALPHA protein]], RXRA protein promotes the reaction [Calcitriol promotes the reaction [NCOA1 protein binds to VDR protein]], RXRA protein promotes the reaction [Calcitriol promotes the reaction [NCOA1 protein binds to VDRB protein]], RXRA protein promotes the reaction [Calcitriol promotes the reaction [NCOA2 protein binds to VDR protein]], RXRA protein promotes the reaction [Calcitriol promotes the reaction [NCOA2 protein binds to VDRB protein]], U 0126 inhibits the reaction [Calcitriol promotes the reaction [MAPK1 protein results in increased phosphorylation of RXRA protein]], U 0126 inhibits the reaction [Calcitriol promotes the reaction [MAPK3 protein results in increased phosphorylation of RXRA protein]], U 0126 inhibits the reaction [Calcitriol promotes the reaction [RXRA protein binds to CYP7A1 mRNA]]

PMID:11504768, PMID:15578590, PMID:15919092, PMID:16204233, PMID:19106115, PMID:19244278, PMID:20153625, PMID:20371703, PMID:21917910, PMID:25279795, PMID:27107558
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.