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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1566394
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Adam8
Name: ADAM metallopeptidase domain 8
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13430506480464CTDCalcitriol results in decreased expression of ADAM8 mRNA

PMID:26485663
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