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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2894
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Il1rl1
Name: interleukin 1 receptor-like 1
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7361586480464CTDCalcitriol results in increased expression of IL1RL1 mRNA

PMID:12040012, PMID:16002434, PMID:26485663
multiple interactionsISORGD:7361586480464CTDKetoconazole promotes the reaction [Calcitriol results in increased expression of IL1RL1 mRNA]

PMID:12040012
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.