GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69358
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Sost
Name: sclerostin
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISOCRRD:7373346480464CTDCalcitriol promotes the reaction [BMP2 protein results in increased expression of SOST mRNA]

Calcitriol promotes the reaction [BMP4 protein results in increased expression of SOST mRNA]

Calcitriol promotes the reaction [BMP6 protein results in increased expression of SOST mRNA]

PMID:15268896
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.