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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 733705
Species: Homo sapiens
CRRD Object: Gene
Symbol: CTNNB1
Name: catenin beta 1
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDCalcitriol results in decreased activity of CTNNB1 protein

PMID:16051482
multiple interactionsEXP 6480464CTD[Calcitriol binds to VDR protein] which results in decreased activity of CTNNB1 mRNA, Calcitriol inhibits the reaction [CTNNB1 protein results in increased expression of DKK4 mRNA], Calcitriol promotes the reaction [CTNNB1 protein binds to VDR protein]

PMID:16051482, PMID:20043299
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.