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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 737414
Species: Mus musculus
CRRD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7374136480464CTDCalcitriol results in increased expression of CDH1, Calcitriol results in increased expression of CDH1 mRNA, Calcitriol results in increased expression of CDH1 protein

PMID:11519864, PMID:16051482, PMID:26485663
multiple interactionsISORGD:7374136480464CTD[Calcitriol binds to and results in increased activity of VDR protein] which results in increased expression of CDH1 mRNA

PMID:15489543
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.