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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69313
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ache
Name: acetylcholinesterase
Acc ID: CHEBI:17941
Term: diisopropyl fluorophosphate
Definition: A dialkyl phosphate that has formula C6H14FO3P.
Chemical ID: MESH:D007531
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDIsoflurophate analog results in decreased activity of ACHE protein

Isoflurophate results in decreased activity of ACHE protein

PMID:1609424, PMID:21513723, PMID:22986948, PMID:26965078, PMID:29272548, PMID:29894704, PMID:3215484, PMID:7150809, PMID:7178195, PMID:7234437, PMID:7713347, PMID:8336138
decreases expressionEXP 6480464CTDIsoflurophate results in decreased expression of ACHE mRNA

PMID:24291005
decreases activityISOCRRD:7358786480464CTDIsoflurophate results in decreased activity of ACHE protein

PMID:18344198, PMID:20227398, PMID:20888407, PMID:21673941, PMID:24395470, PMID:26965078, PMID:9268605, PMID:9515941
decreases activityISOCRRD:7358796480464CTDIsoflurophate results in decreased activity of ACHE protein

PMID:16978018, PMID:21767560, PMID:22209767, PMID:24395470, PMID:26965078, PMID:9268605, PMID:9515941
decreases response to substanceISOCRRD:7358796480464CTDACHE protein results in decreased susceptibility to Isoflurophate

ACHE results in decreased susceptibility to Isoflurophate

PMID:16443250, PMID:17192637, PMID:21783513
multiple interactionsISOCRRD:7358786480464CTDFullerenes analog inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]

Glucosides inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]

N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]

Obidoxime Chloride inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]

Oximes inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]

pralidoxime inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]

Trimedoxime inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]

PMID:18344198, PMID:20227398, PMID:20888407
multiple interactionsISOCRRD:7358796480464CTDIsoflurophate binds to and results in increased phosphorylation of and results in decreased activity of ACHE protein

PMID:17402711
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.