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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620634
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Hr
Name: HR, lysine demethylase and nuclear receptor corepressor
Acc ID: CHEBI:18258
Term: 3,3',5-triiodo-L-thyronine
Definition: An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
Chemical ID: MESH:D014284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISOCRRD:13449846480464CTDTriiodothyronine results in increased expression of HR mRNA

PMID:26096596
increases expressionISOCRRD:7357966480464CTDTriiodothyronine results in increased expression of HR mRNA

PMID:25172293
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.