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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2466
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp2b1
Name: cytochrome P450, family 2, subfamily b, polypeptide 1
Acc ID: CHEBI:18358
Term: methoxsalen
Definition: A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
Chemical ID: MESH:D008730
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDMethoxsalen results in decreased activity of CYP2B1 protein

PMID:15879494
decreases activityISORGD:15583116480464CTDMethoxsalen results in decreased activity of CYP2B10 protein

PMID:18420780
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.