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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61312
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:21759
Term: N-methyl-N'-nitro-N-nitrosoguanidine
Definition: An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position
Chemical ID: MESH:D008769
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDMethylnitronitrosoguanidine results in decreased expression of TIMP2 mRNA, Methylnitronitrosoguanidine results in decreased expression of TIMP2 protein

PMID:20434464
multiple interactionsEXP 6480464CTDEugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TIMP2 mRNA], Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TIMP2 protein]

PMID:20434464
multiple interactionsISORGD:621786480464CTD[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of TIMP2 mRNA, [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of TIMP2 mRNA, [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of TIMP2 mRNA

PMID:19840844
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.