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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2414
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cryab
Name: crystallin, alpha B
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases response to substanceISORGD:104006480464CTDCRYAB protein results in decreased susceptibility to Cadmium

PMID:15590893
increases expressionISORGD:104006480464CTDCadmium results in increased expression of CRYAB protein

PMID:15590893
increases expressionISORGD:7375186480464CTDCadmium results in increased expression of CRYAB mRNA

PMID:21120746
multiple interactionsISORGD:104006480464CTD[arsenite co-treated with Cadmium] promotes the reaction [Mercury results in increased expression of CRYAB protein], [arsenite co-treated with Mercury] promotes the reaction [Cadmium results in increased expression of CRYAB protein], [Mercury co-treated with Cadmium] promotes the reaction [arsenite results in increased expression of CRYAB protein], arsenite promotes the reaction [Cadmium results in increased expression of CRYAB protein], Cadmium promotes the reaction [arsenite results in increased expression of CRYAB protein]

PMID:15590893
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.