GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1305729
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Lrp8
Name: LDL receptor related protein 8
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISOCRRD:13139326480464CTDAflatoxin B1 affects the expression of LRP8 protein

PMID:20106945
decreases expressionISOCRRD:13139326480464CTDAflatoxin B1 results in decreased expression of LRP8 mRNA

PMID:21632981, PMID:21641981
increases expressionISOCRRD:13139326480464CTDAflatoxin B1 results in increased expression of LRP8 mRNA

PMID:22100608
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.