GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2459
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:254496
Term: 7,12-dimethyltetraphene
Definition: A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.
Chemical ID: MESH:D015127
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityEXP 6480464CTD9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1A2 protein

PMID:16054776
increases activityISOCRRD:104386480464CTDCYP1A2 protein results in increased activity of 9,10-Dimethyl-1,2-benzanthracene

PMID:15606143
increases activityISOCRRD:7357116480464CTD9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1A2 protein

PMID:17183067
increases expressionISOCRRD:7357116480464CTD9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A2 mRNA

PMID:17183067, PMID:19276279, PMID:25110319
multiple interactionsISOCRRD:104386480464CTD[CYP1A2 protein co-treated with Trichloroepoxypropane] results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene

EPHX1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]

PMID:8961944
multiple interactionsISOCRRD:7357116480464CTD2-((2,6-dichlorophenyl)amino)benzeneacetic acid 4-(3H-1,2-dithiol-3-thione-5-yl)phenyl ester inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A2 mRNA]

3-(3-methoxyphenyl)-N-(3,4,5-trimethoxyphenyl)acrylamide inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1A2 protein]

3-(3-methoxyphenyl)-N-(3,4,5-trimethoxyphenyl)acrylamide inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A2 mRNA]

[CYP1A2 protein co-treated with Trichloroepoxypropane] results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene

EPHX1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]

isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A2 mRNA]

S-sulindac inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A2 mRNA]

PMID:17183067, PMID:19276279, PMID:25110319, PMID:8961944
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.